rs11166440

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele G

OR 9.46

p 3.0e-21

N 1,508,659

Large GWAS

multi-ancestry

Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)

Allele G

OR 0.00

p 4.0e-17

N 1,004,040

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 1.0e-12

N 571,227

Major Consortium StudyLarge GWAS

multi-ancestry

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele G

OR 0.00

p 4.0e-13

N 567,460

Large GWAS

European

Graham SE et al. “Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.” Nature Communications 10(1):1847 (2019)

Allele G

OR 5.79

p 7.0e-9

N 350,514

Meta-analysisLarge GWAS

multi-ancestry

serum creatinine amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.02

p 2.0e-14

N 602,615

Major Consortium StudyLarge GWAS

multi-ancestry

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.01

p 7.0e-17

N 450,015

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs11166440

GWAS Catalog Trait Associations (2)

glomerular filtration rate

serum creatinine amount

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