rs11206127

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

irritable bowel syndrome

Alemany S et al. “Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.” Journal of Translational Medicine 21(1):272 (2023)
Allele A
OR 0.01
p 1.0e-8
N 887,490
Large GWAS
European
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Research that mentions this SNP (1)

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Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction
AssociationN=4,873Wolfgang Lieb et al.(2008)· Journal of Molecular Medicine

This association study tested whether genetic variants in the LRP8 gene are associated with myocardial infarction (MI) and coronary artery disease (CAD) in German familial MI families and the Wellcome Trust Case Control Consortium cohort. The authors found no significant association between LRP8 SNPs and MI/CAD risk across multiple populations, including analysis of rs5177 (a proxy for the reported rs5174/R952Q variant) and 13 additional LRP8 variants with ORs ranging from 0.80-1.19.

Traits studied:Coronary artery diseaseMyocardial infarction
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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