rs11206244

Genetic association study of cancer cachexia identified 129 SNPs in 80 candidate genes in 775 cancer patients. The C allele of rs6136 in the SELP gene (encoding P-selectin) was significantly associated with reduced risk of cancer cachexia (weight loss >10%) in both the main study (OR 0.52; p=0.026) and validation cohort (OR 0.09; p=0.035). Multiple other genes including APEH, GHRL, TNFRSF1A, and CNR1 showed significant associations with cachexia-related traits.

This candidate gene study examined 12 SNPs from genome-wide association studies of thyroid function in 1,555 subjects from three independent cohorts, testing associations with major depression and thyroid hormones. The authors confirmed that the DIO1 variant rs11206244 (T allele) was associated with increased free thyroxine (FT4) levels in both ethnic groups (p<0.004 in White females). Notably, rs11206244 genotype was associated with lifetime major depression in White female subjects from high-risk cohorts (p<0.004), but not in African American subjects or White males. Current FT4 levels were not associated with lifetime depression, suggesting thyroid changes in depression are state-dependent rather than trait-dependent.