rs11212617

This is a intron variant variant in the C11orf65 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

response to metformin

Zhou K et al. “Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.” Nature Genetics 43(2):117-20 (2011)
Allele C
OR 1.35
p 3.0e-9
N 1,024
Large GWAS
European
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Research that mentions this SNP (1)

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A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts
Meta-analysisN=4,443van Leeuwen N. et al.(2012)· Diabetologia

A meta-analysis of five cohorts (DCS, Rotterdam Study, CARDS, GoDARTS, UKPDS) examined the association between SNP rs11212617 near the ATM gene and metformin treatment response in type 2 diabetes. The C allele was significantly associated with improved treatment success (ability to reach HbA1c ≤7%, OR 1.25, 95% CI 1.13-1.38, p=7.8×10^-6 in combined meta-analysis of 4,443 patients) and a decrease in HbA1c of -0.050% per C allele (p=0.013). This represents the first robustly replicated common susceptibility locus associated with metformin response.

Traits studied:HbA1c reductionMetformin treatment responseType 2 diabetes
PubMedDOIMetascience Observatory

About C11orf65

Predicted to be involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Predicted to be located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all C11orf65 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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