rs11214775

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Schumacher FR et al. “Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.” Nature Genetics 50(7):928-936 (2018)
Allele G
OR 1.07
p 4.0e-15
N 140,254
Large GWAS
European
Al Olama AA et al. “A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.” Nature Genetics 46(10):1103-9 (2014)
Allele G
OR 1.08
p 3.0e-8
N 87,040
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data
AssociationN=3,564Jiekun Yang et al.(2014)· Human Genetics

This association study examined 3,564 subjects from the SAGE dataset (2,428 European-American, 1,136 African-American) to determine associations between 88 variants in HTR3A, HTR3B, and SLC6A4 genes and alcohol, cocaine, and nicotine dependence. Individual SNP analysis found rs2066713 in SLC6A4 significantly associated with FTND in African-Americans (beta = -1.39, P = 1.6E-04). Haplotype analysis identified major haplotypes in HTR3B and HTR3A significantly associated with alcohol dependence and FTND. GMDR interaction analysis revealed significant SNP-by-SNP interactions within these three genes affecting multiple addictive phenotypes.

Traits studied:Alcohol DependenceCocaine DependenceFagerström Test for Nicotine DependenceNicotine Dependence
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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