rs11255841

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

colorectal cancer

Fernandez-Rozadilla C et al. “Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.” Nature Genetics 55(1):89-99 (2023)
Allele A
OR 0.11
p 3.0e-58
N 254,791
Large GWAS
multi-ancestry
Schmit SL et al. “Novel Common Genetic Susceptibility Loci for Colorectal Cancer.” Journal of the National Cancer Institute 111(2):146-157 (2019)
Allele A
OR 1.10
p 3.0e-12
N 67,812
Large GWAS
multi-ancestry
Tanikawa C et al. “GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.” Carcinogenesis 39(5):652-660 (2018)
Allele A
OR 1.17
p 2.0e-14
N 33,870
Large GWAS
East Asian
Al-Tassan NA et al. “A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.” Scientific Reports 5:10442 (2015)
Allele A
OR 1.18
p 4.0e-13
N 17,556
Meta-analysisLarge GWAS
European
Whiffin N et al. “Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.” Human Molecular Genetics 23(17):4729-37 (2014)
Allele A
OR 1.19
p 7.0e-11
N 13,443
Meta-analysisLarge GWAS
European

colorectal cancer, colorectal adenoma

Huyghe JR et al. “Discovery of common and rare genetic risk variants for colorectal cancer.” Nature Genetics 51(1):76-87 (2019)
Allele T
OR 1.09
p 2.0e-21
N 125,478
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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The CDH1‐160C&gt;A polymorphism is a risk factor for colorectal cancer
AssociationN=1,926Alan M. Pittman et al.(2009)· International Journal of Cancer

This study examined the relationship between 233 colorectal cancer (CRC) risk loci and overall survival in 1,926 patients with advanced CRC from clinical trials. Two SNPs significantly associated with survival under a recessive model were identified: rs117079142 (HR=2.79, 95% CI=1.70-4.58, P=4.7×10⁻⁵) mapping to UTP23/EIF3H, and rs9924886 (HR=1.24, 95% CI=1.12-1.38, P=5.2×10⁻⁵) mapping to CDH1/CDH3. Low CDH1 gene expression in tumors was associated with worse survival (HR=2.18, P=1.8×10⁻³), supporting a prognostic role for CDH1 variants.

Traits studied:Colorectal cancerColorectal cancer prognosisOverall survival in advanced colorectal cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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