rs1126464

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GWAS Catalog Trait Associations (25)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cys-gly, oxidized measurement

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele C

OR 0.57

p 2.0e-191

N 7,081

Large GWAS

multi-ancestry

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele C

OR 0.45

p 3.0e-141

N 8,256

Large GWAS

European

serum metabolite level

Feofanova EV et al. “A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.” American Journal of Human Genetics 107(5):849-863 (2020)

Allele G

OR 0.60

p 2.0e-122

N 3,926

Large GWAS

Hispanic or Latin American

cysteinylglycine disulfide measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele C

OR 0.34

p 1.0e-76

N 8,216

Large GWAS

European

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele C

OR 0.50

p 2.0e-47

N 2,433

Large GWAS

multi-ancestry

body height

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 7.0e-56

N 525,444

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.04

p 4.0e-24

N 607,510

Major Consortium StudyLarge GWAS

multi-ancestry

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)

Allele C

OR 0.02

p 6.0e-25

N 405,540

Large GWAS

European

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele C

OR 0.04

p 6.0e-49

N 153,950

Large GWAS

East Asian

cysteinylglycine measurement

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele C

OR 0.31

p 5.0e-49

N 6,143

Large GWAS

multi-ancestry

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele C

OR 0.25

p 2.0e-42

N 8,214

Large GWAS

European

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)

Allele C

OR 0.15

p 2.0e-16

N 4,688

Large GWAS

European

level of carboxypeptidase A1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.08

p 2.0e-48

N 47,745

Large GWAS

European

carboxypeptidase B measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.08

p 2.0e-42

N 47,745

Large GWAS

European

trypsin-2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.08

p 2.0e-39

N 47,745

Large GWAS

European

diastolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele C

OR 0.21

p 6.0e-33

N 1,028,980

Large GWAS

multi-ancestry

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele C

OR 0.23

p 1.0e-20

N 526,001

Large GWAS

European

Surendran P et al. “Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.” Nature Genetics 48(10):1151-1161 (2016)

Allele C

OR 0.25

p 6.0e-15

N 192,763

Large GWAS

multi-ancestry

Liu C et al. “Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.” Nature Genetics 48(10):1162-70 (2016)

Allele C

OR 0.24

p 2.0e-13

N 146,562

Meta-analysisLarge GWAS

multi-ancestry

inactive pancreatic lipase-related protein 1 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.07

p 1.0e-32

N 47,745

Large GWAS

European

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele C

OR 0.11

p 8.0e-13

N 10,708

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs1126464

GWAS Catalog Trait Associations (25)

cys-gly, oxidized measurement

serum metabolite level

cysteinylglycine disulfide measurement

body height

cysteinylglycine measurement

level of carboxypeptidase A1 in blood

carboxypeptidase B measurement

trypsin-2 measurement

diastolic blood pressure

inactive pancreatic lipase-related protein 1 measurement

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