rs112653955
This is a downstream gene variant variant in the ZNF454 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
information processing speed, cognitive function measurement, major depressive disorder
Thalamuthu A et al. “Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.” Molecular Psychiatry 27(2):1111-1119 (2022)
Allele A
OR —
p 9.0e-9
N 9,567
Large GWAS
European
About ZNF454
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNF454 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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