rs1134688

This is a synonymous variant in the CZIB gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lipid measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.26
p 7.0e-90
N 14,296
Large GWAS
European

metabolite measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.23
p 1.0e-78
N 14,296
Large GWAS
European
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele T
OR 0.26
p 2.0e-40
N 4,907
Large GWAS
European

glutarylcarnitine (C5-DC) measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele G
OR 0.25
p 6.0e-44
N 8,238
Large GWAS
European

3-methylglutarylcarnitine (2) measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.14
p 6.0e-29
N 14,296
Large GWAS
European

About CZIB

Enables zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

View all CZIB variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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