rs11465788
This variant is located in the IL23R gene.
▶Research that mentions this SNP (1)
▶Interleukin-23 receptor genetic polymorphisms and Crohn’s disease susceptibility: a meta-analysisMeta-analysisN=14,100Yi Li et al.(2010)· Inflammation Research
Meta-analysis of 18 case-control studies examining IL-23R polymorphisms and Crohn's disease (CD) susceptibility. Two polymorphisms showed significant protective associations: rs11209026 (Arg381Gln) with OR=0.43 (95% CI: 0.37-0.50, P<0.00001) and rs7517847 with OR=0.49 (95% CI: 0.38-0.64, P<0.00001 for G/G vs. T/T comparison). Other examined SNPs (rs1004819, rs10889677, rs1495965) showed no significant associations. Caucasian populations showed the strongest protective effects for Arg381Gln.
About IL23R
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
View all IL23R variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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