rs114725221

This is a intron variant variant in the LMNB1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multiple epidermal growth factor-like domains protein 10 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.13

p 2.0e-12

N 47,745

Large GWAS

European

About LMNB1

This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

View all LMNB1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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