rs114872993

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

response to anticonvulsant

Ada Man‐Choi Ho et al. “Mood‐Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome‐Wide Association Study” Clinical Pharmacology &amp; Therapeutics (2020)
Allele G
OR 4.50
p 3.0e-8
N 199
Small GWAS
European
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Research that mentions this SNP (1)

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Mood‐Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome‐Wide Association Study
AssociationN=199Ada Man‐Choi Ho et al.(2020)· Clinical Pharmacology &amp; Therapeutics

A genome-wide association study of 199 bipolar disorder patients identified two genome-wide significant SNP signals: rs78835388 in THSD7A (P = 7.1E-09) and rs114872993 in SLC35F3 (P = 3.2E-08) associated with mood-stabilizing antiepileptic drug (AED-MS) treatment response. Gene-level analysis also identified significant associations in ABCC1 (top SNP rs875740, P = 2.0E-6) and DISP1 (top SNP rs34701716, P = 8.9E-07). The findings suggest potential genetic markers for predicting AED-MS response in bipolar disorder treatment.

Traits studied:Antiepileptic mood stabilizer treatment responseBipolar disorder
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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