rs115034159

This is a upstream gene variant variant in the GNG8 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

abdominal fat cell number

Kulyté A et al. “Genome-Wide Association Study Identifies Genetic Loci Associated With Fat Cell Number and Overlap With Genetic Risk Loci for Type 2 Diabetes.” Diabetes 71(6):1350-1362 (2022)

Allele T

OR 0.18

p 2.0e-9

N 896

Small GWAS

color vision disorder

Nardone GG et al. “Identifying missing pieces in color vision defects: a genome-wide association study in Silk Road populations.” Frontiers in Genetics 14:1161696 (2023)

Allele T

OR 0.22

p 2.0e-8

N 520

Small GWAS

Other

About GNG8

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Jul 2025]

View all GNG8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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