rs11507683
This is a synonymous variant in the EXD3 gene — it does not change the protein's amino acid sequence.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body mass index
Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele C
OR 0.02
p 7.0e-17
N 1,122,049
Large GWAS
European
depressive symptom measurement
Li ZY et al. “Whole exome sequencing identified six novel genes for depressive symptoms.” Molecular Psychiatry 30(5):1925-1936 (2025)
Allele T
OR 0.02
p 7.0e-10
N 296,199
Large GWAS
European
post-traumatic stress disorder symptom measurement
Stein MB et al. “Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.” Nature Genetics 53(2):174-184 (2021)
Allele T
OR 0.18
p 8.0e-9
N 186,689
Major Consortium StudyLarge GWAS
European
Back pain
Freidin MB et al. “Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals.” Pain 160(6):1361-1373 (2019)
Allele T
OR 0.04
p 1.0e-8
N 453,862
Large GWAS
European
About EXD3
Predicted to enable 3'-5' exonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be involved in nucleobase-containing compound metabolic process. [provided by Alliance of Genome Resources, Jul 2025]
View all EXD3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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