rs1152591

This is a intron variant variant in the SYNE2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atrial fibrillation

Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)
Allele A
OR 0.08
p 2.0e-124
N 2,584,013
Large GWAS
multi-ancestry
Christophersen IE et al. “Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.” Nature Genetics 49(6):946-952 (2017)
Allele A
OR 1.09
p 1.0e-10
N 133,073
Large GWAS
multi-ancestry
Ellinor PT et al. “Meta-analysis identifies six new susceptibility loci for atrial fibrillation.” Nature Genetics 44(6):670-675 (2012)
Allele A
OR 1.13
p 6.0e-13
N 59,133
Meta-analysisLarge GWAS
European
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ClinVar annotation

Benign★★★☆
2 submitters1 publication
View on ClinVar →
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Research that mentions this SNP (1)

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Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals
AssociationN=17,325Jason D. Roberts et al.(2016)· JAMA Cardiology

This genome-wide admixture analysis of three population-based cohorts (CHS, ARIC, Health ABC; n=17,325) investigated whether 9 known atrial fibrillation (AF) SNPs explain the paradoxically higher AF risk in Whites compared to Blacks. Using Cox proportional hazards models, rs10824026 (in SYNPO2L/MYOZ1) significantly mediated 11.4% (95% CI 2.9-29.9%) and 31.7% (95% CI 16.0-53.0%) of the excess AF risk in Whites in CHS and ARIC respectively. Admixture mapping across 4,938 Black participants identified no loci reaching genome-wide significance (p<7×10⁻⁶), suggesting the racial differential in AF risk is driven by multiple genetic and/or environmental factors rather than single variants.

Traits studied:Atrial fibrillation
PubMedDOIMetascience Observatory

About SYNE2

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

View all SYNE2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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