rs115391969
This is a intron variant variant in the MYLK3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
soluble CD163 measurement
Durda P et al. “Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study.” Journal of the American Heart Association 11(21):e024374 (2022)
Allele T
OR 159.60
p 4.0e-8
N 763
Small GWAS
African American or Afro-Caribbean
About MYLK3
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
View all MYLK3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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