rs1154155

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

narcolepsy-cataplexy syndrome

Ollila HM et al. “Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.” Nature Communications 14(1):2709 (2023)

Allele C

OR 0.48

p 7.0e-86

N 90,929

Large GWAS

multi-ancestry

Faraco J et al. “ImmunoChip study implicates antigen presentation to T cells in narcolepsy.” Plos Genetics 9(2):e1003270 (2013)

Allele C

OR 1.72

p 9.0e-30

N 12,307

Large GWAS

European

Han F et al. “Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.” Plos Genetics 9(10):e1003880 (2013)

Allele C

OR 1.64

p 5.0e-49

N 3,186

Large GWAS

multi-ancestry

Toyoda H et al. “A polymorphism in CCR1/CCR3 is associated with narcolepsy.” Brain, Behavior, and Immunity 49:148-55 (2015)

Allele C

OR 1.71

p 1.0e-11

N 1,971

Large GWAS

East Asian

Hallmayer J et al. “Narcolepsy is strongly associated with the T-cell receptor alpha locus.” Nature Genetics 41(6):708-11 (2009)

Allele C

OR 1.69

p 3.0e-22

N 1,881

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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