rs11553699

▶

GWAS Catalog Trait Associations (33)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet count

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.16

p —

N 928,679

Large GWAS

multi-ancestry

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele A

OR 0.08

p 2.0e-178

N 542,827

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele A

OR 0.11

p 5.0e-214

N 499,097

Large GWAS

multi-ancestry

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele A

OR 0.08

p 4.0e-127

N 408,112

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.09

p 1.0e-83

N 406,601

Major Consortium StudyLarge GWAS

European

Xiang R et al. “Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.” Nature Communications 16(1):4260 (2025)

Allele A

OR 0.03

p 2.0e-17

N 391,231

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele A

OR 0.08

p 1.0e-45

N 166,066

Large GWAS

European

Little A et al. “Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative.” Human Molecular Genetics 31(3):347-361 (2022)

Allele A

OR 4.26

p 6.0e-12

N 61,200

Large GWAS

multi-ancestry

Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)

Allele A

OR 0.11

p 2.0e-10

N 38,000

Large GWAS

South Asian

platelet volume

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.39

p —

N 408,112

Large GWAS

European

Xiang R et al. “Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.” Nature Communications 16(1):4260 (2025)

Allele G

OR 0.04

p 9.0e-26

N 391,597

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.37

p —

N 164,454

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.32

p 2.0e-119

N 40,412

Major Consortium StudyLarge GWAS

Hispanic or Latin American

Hu Y et al. “Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.” Bmc Genomics 22(1):432 (2021)

Allele G

OR 0.38

p 2.0e-26

N 21,347

Large GWAS

Hispanic or Latin American

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR 0.36

p 2.0e-9

N 10,737

Large GWAS

African American or Afro-Caribbean, African unspecified

platelet component distribution width

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.11

p 2.0e-212

N 408,112

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.16

p 1.0e-184

N 164,433

Large GWAS

European

platelet crit

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.11

p 9.0e-196

N 408,112

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.11

p 6.0e-81

N 164,339

Large GWAS

European

level of syndecan-4 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.15

p 6.0e-91

N 47,745

Large GWAS

European

proheparin-binding EGF-like growth factor level

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.15

p 1.0e-80

N 47,745

Large GWAS

European

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele G

OR 0.20

p 7.0e-24

N 10,708

Large GWAS

European

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele G

OR 0.26

p 4.0e-12

N 3,301

Large GWAS

European

immature platelet count

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.18

p 6.0e-58

N 36,618

Large GWAS

European

peroxisome proliferator-activated receptor alpha measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele A

OR 0.28

p 2.0e-47

N 10,708

Large GWAS

European

mitochondrial DNA measurement

Chong M et al. “GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.” Elife 11 (2022)

Allele G

OR 0.04

p 1.0e-43

N 395,718

Large GWAS

European, South Asian, African unspecified

Gupta R et al. “Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.” Nature 620(7975):839-848 (2023)

Allele G

OR 0.03

p 2.0e-10

N 163,372

Large GWAS

multi-ancestry

platelet reactivity efficacy

Verdier H et al. “A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk.” Blood 142(22):1895-1908 (2023)

Allele G

OR 0.13

p 4.0e-35

N 29,806

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs11553699

GWAS Catalog Trait Associations (33)

platelet count

platelet volume

platelet component distribution width

platelet crit

level of syndecan-4 in blood

proheparin-binding EGF-like growth factor level

immature platelet count

peroxisome proliferator-activated receptor alpha measurement

mitochondrial DNA measurement

platelet reactivity efficacy

Community Wiki

Comments