rs11575837

This variant is located in the NCR3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

17-hydroxyprogesterone measurement

Pott J et al. “Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease.” The Journal of Clinical Endocrinology and Metabolism 104(11):5008-5023 (2019)

Allele T

OR 0.58

p 8.0e-13

N 2,070

Large GWAS

European

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ClinVar annotation

Pathogenic

1 submitter

Malaria, severe, susceptibility to

View on ClinVar →

About NCR3

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

View all NCR3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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