rs115777389
This is a regulatory region variant variant in the ACY3 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of N-acyl-aromatic-L-amino acid amidohydrolase, carboxylate-forming in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele G
OR 1.21
p 6.0e-17
N 466
Small GWAS
African American or Afro-Caribbean
metabolite measurement
Tahir UA et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.” Nature Communications 13(1):4923 (2022)
Allele G
OR 0.71
p 6.0e-27
N 2,466
Large GWAS
multi-ancestry
About ACY3
Predicted to enable aminoacylase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
View all ACY3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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