rs11591710

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chromosome, telomeric region length

Liu WS et al. “Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications.” Geroscience 46(5):5365-5385 (2024)

Allele C

OR 0.08

p 6.0e-106

N 327,790

Large GWAS

European

thyroid carcinoma

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele C

OR 0.19

p 3.0e-29

N 2,106,366

Large GWAS

European

nodular goiter

Allele C

OR 0.07

p 7.0e-19

N 2,460,445

Large GWAS

multi-ancestry

lung adenocarcinoma

McKay JD et al. “Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.” Nature Genetics 49(7):1126-1132 (2017)

Allele C

OR 1.16

p 6.0e-11

N 66,756

Large GWAS

European

neuroblastoma, cutaneous melanoma

Avitabile M et al. “Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene.” Carcinogenesis 41(3):284-295 (2020)

Allele C

OR 1.12

p 6.0e-10

N 42,380

Large GWAS

European

clear cell renal carcinoma

Purdue MP et al. “Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions.” Nature Genetics 56(5):809-818 (2024)

Allele C

OR 1.11

p 3.0e-8

N 759,800

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs11591710

GWAS Catalog Trait Associations (6)

chromosome, telomeric region length

thyroid carcinoma

nodular goiter

lung adenocarcinoma

neuroblastoma, cutaneous melanoma

clear cell renal carcinoma

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