rs11623779

This is a intron variant variant in the RIN3 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum albumin amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.03

p 1.0e-15

N 542,272

Major Consortium StudyLarge GWAS

multi-ancestry

forced expiratory volume, 25-hydroxyvitamin D3 measurement

Seo J et al. “Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.” The American Journal of Clinical Nutrition 119(5):1227-1237 (2024)

Allele C

OR —

p 2.0e-9

N 115,312

Meta-analysisLarge GWAS

multi-ancestry

preserved ratio impaired spirometry

Higbee DH et al. “Genome-wide association study of preserved ratio impaired spirometry (PRISm).” The European Respiratory Journal 63(1) (2024)

Allele T

OR 1.01

p 2.0e-8

N 289,782

Large GWAS

European

About RIN3

Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]