rs116446171

This is a regulatory region variant variant.

▶

GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Waldenstrom macroglobulinemia

McMaster ML et al. “Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia.” Nature Communications 9(1):4182 (2018)
Allele G
OR 21.14
p 1.0e-54
N 4,015
Large GWAS
European

immunoglobulin J chain measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.20
p 2.0e-23
N 47,745
Large GWAS
European

diffuse large B-cell lymphoma

Cerhan JR et al. “Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.” Nature Genetics 46(11):1233-8 (2014)
Allele G
OR 2.20
p 2.0e-21
N 11,523
Large GWAS
European

CD5 antigen-like measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.16
p 1.0e-17
N 47,745
Large GWAS
European

plasma protein metabolism disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.42
p 2.0e-15
N 627,057
Major Consortium StudyLarge GWAS
multi-ancestry

eosinophil percentage of leukocytes

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.05
p 5.0e-14
N 394,642
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…