rs11651755

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)
Allele C
OR 0.07
p 9.0e-67
N 1,407,282
Meta-analysisLarge GWAS
multi-ancestry
Xue A et al. “Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.” Nature Communications 9(1):2941 (2018)
Allele C
OR 0.07
p 9.0e-22
N 659,316
Large GWAS
multi-ancestry

glucose measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.02
p 8.0e-17
N 448,252
Large GWAS
multi-ancestry
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.01
p 7.0e-12
N 394,642
Large GWAS
European

diabetes mellitus

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.08
p 3.0e-12
N 394,626
Large GWAS
European

ovarian clear cell adenocarcinoma

Phelan CM et al. “Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.” Nature Genetics 49(5):680-691 (2017)
Allele T
OR 1.27
p 7.0e-9
N 42,307
Large GWAS
European

ovarian carcinoma

Phelan CM et al. “Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.” Nature Genetics 49(5):680-691 (2017)
Allele C
OR 1.08
p 8.0e-9
N 85,426
Large GWAS
European

ovarian serous carcinoma

Phelan CM et al. “Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.” Nature Genetics 49(5):680-691 (2017)
Allele C
OR 1.09
p 1.0e-8
N 54,990
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease
AssociationN=856Xu Zhang et al.(2015)· Human Genetics

This GWAS meta-analysis of 856 sickle cell disease (SCD) adults identified rs59014890 in APOB as associated with diabetes risk (P=3.2×10−8, OR=17-18), where the C allele paradoxically decreased APOB expression in peripheral blood mononuclear cells but increased diabetes risk. The association was validated in adolescent SCD patients for overweight status and in African Americans ≥45 years with BMI >25 kg/m² for diabetes risk, demonstrating a gene-by-environment interaction. Lower APOB expression also correlated with elevated hemoglobin A1C and serum lipids in Chuvash polycythemia patients.

Traits studied:Hemoglobin A1COverweight/obesityPlasma lipid concentrationsSickle cell diseaseTotal cholesterolTriglyceridesType 2 diabetes mellitus
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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