rs11653545
This variant is located in the FXR2 gene.
▶Research that mentions this SNP (1)
▶Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokersAssociationN=3,495Chen Yang et al.(2012)· Immunogenetics
Two-stage genome-wide association study in 3,495 healthy Chinese men identified TNFSF13 as a susceptibility locus for serum IgA levels. The lead variant rs3803800 showed significant association (P = 6.26×10⁻⁸ in stage 1, combined P = 2.97×10⁻⁷), with markedly stronger association in smokers (P = 3.96×10⁻⁷) compared to nonsmokers (P = 2.28×10⁻¹), suggesting smoking modulates the genetic effect on IgA levels.
About FXR2
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]
View all FXR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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