rs11659764
▶GWAS Catalog Trait Associations (20)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (20)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Fuchs endothelial corneal dystrophy
Gorman BR et al. “A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation.” Communications Biology 7(1):418 (2024)
Allele A
OR 7.15
p —
N 258,564
Large GWAS
European
corneal resistance factor
Simcoe MJ et al. “Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases.” Human Molecular Genetics 29(18):3154-3164 (2020)
Allele T
OR 0.33
p 4.0e-92
N 106,030
Large GWAS
European
Jiang X et al. “Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants.” Communications Biology 3(1):762 (2020)
Allele T
OR 0.34
p 2.0e-65
N 76,029
Large GWAS
European
Khawaja AP et al. “Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association Study.” Jama Ophthalmology 137(9):1005-1012 (2019)
Allele T
OR 0.32
p 4.0e-9
N 6,645
Large GWAS
European
corneal hysteresis
Simcoe MJ et al. “Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases.” Human Molecular Genetics 29(18):3154-3164 (2020)
Allele T
OR 0.28
p 2.0e-77
N 106,041
Large GWAS
European
Fuchs' endothelial dystrophy
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 1.97
p 1.0e-21
N 121,609
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
intraocular pressure measurement
Gao XR et al. “Genome-wide association analyses identify new loci influencing intraocular pressure.” Human Molecular Genetics 27(12):2205-2213 (2018)
Allele T
OR 0.28
p 6.0e-20
N 115,486
Large GWAS
European
Abnormality of the skeletal system
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 9.0e-18
N 394,642
Large GWAS
European
base metabolic rate measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 2.0e-15
N 394,642
Large GWAS
European
whole body water mass
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 4.0e-15
N 394,642
Large GWAS
European
body mass index
Hawkes G et al. “Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.” Diabetologia 66(8):1472-1480 (2023)
Allele T
OR 0.03
p 3.0e-13
N 441,761
Large GWAS
European
body weight
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.03
p 8.0e-13
N 394,642
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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