rs11663816

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)

Allele C

OR 0.06

p 4.0e-37

N 123,097

Meta-analysisLarge GWAS

multi-ancestry

waist-hip ratio

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)

Allele T

OR 0.03

p 3.0e-11

N 143,480

Large GWAS

multi-ancestry

urate measurement

Tin A et al. “Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.” Nature Genetics 51(10):1459-1474 (2019)

Allele T

OR 0.04

p 7.0e-12

N 346,213

Large GWAS

European, South Asian, East Asian, African American or Afro-Caribbean, Hispanic or Latin American

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Research that mentions this SNP (1)

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Association Between Common Variants Near the Melanocortin 4 Receptor Gene and Severe Antipsychotic Drug–Induced Weight Gain

AssociationN=344Malhotra AK et al.(2012)· Archives of General Psychiatry

Genome-wide association study of 139 antipsychotic-naïve pediatric patients identified common variants near the MC4R gene (melanocortin 4 receptor) on chromosome 18 associated with severe antipsychotic drug-induced weight gain. The most significant SNPs (rs489693, rs646749, rs12970134) showed p-values ranging from 2.80E-07 to 3.26E-06 in the discovery cohort and replicated in three additional cohorts (n=73, 40, 92). Minor allele homozygotes of rs489693 exhibited significantly greater increases in body fat mass, triglycerides, leptin, insulin, and HOMA-IR.

Traits studied:Antipsychotic-induced weight gainBody mass index (BMI) changeFat massGlucoseHDL cholesterolHOMA-IRInsulinLDL cholesterolLeptinTotal cholesterolTriglycerides

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.