rs116702638
This variant is located in the LONRF2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
response to beta blocker
Fontana V et al. “Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol.” Pharmacogenomics and Personalized Medicine 15:249-260 (2022)
Allele T
OR 12.54
p 3.0e-8
N 622
Small GWAS
European
▶ClinVar annotation
Likely Benign★☆☆☆
1 submitterAbout LONRF2
Predicted to enable misfolded protein binding activity; ribonucleoprotein complex binding activity; and ubiquitin protein ligase activity. Predicted to act upstream of or within several processes, including motor behavior; neuron differentiation; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
View all LONRF2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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