rs11710277

This is a intron variant variant in the SEMA3F gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

thalamus volume

Elvsåshagen T et al. “The genetic architecture of the human thalamus and its overlap with ten common brain disorders.” Nature Communications 12(1):2909 (2021)
Allele G
OR 0.12
p 2.0e-14
N 30,114
Large GWAS
European

taste liking measurement

May-Wilson S et al. “Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.” Nature Communications 13(1):2743 (2022)
Allele G
OR 0.04
p 8.0e-9
N 159,342
Large GWAS
European

alcohol consumption quality

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele G
OR 0.01
p 1.0e-14
N 2,428,851
Large GWAS
European

About SEMA3F

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

View all SEMA3F variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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