rs11710456

This is a intron variant variant in the ST6GAL1 gene.

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IgG galactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 2.0e-90
N 1,960
Large GWAS
European

IgG fucosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 1.0e-88
N 1,960
Large GWAS
European

serum IgG glycosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 6.0e-87
N 1,960
Large GWAS
European
Lauc G et al. “Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.” Plos Genetics 9(1):e1003225 (2013)
Allele G
OR 0.50
p 2.0e-45
N 2,247
Large GWAS
European
Landini A et al. “Genetic regulation of post-translational modification of two distinct proteins.” Nature Communications 13(1):1586 (2022)
Allele G
OR 0.60
p 2.0e-69
N 2,020
Large GWAS
European
Wahl A et al. “Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.” Frontiers in Immunology 9:277 (2018)
Allele G
OR 0.22
p 1.0e-8
N 1,823
Large GWAS
European

IgG digalactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 5.0e-79
N 1,960
Large GWAS
European

IgG monogalactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 3.0e-69
N 1,960
Large GWAS
European

IgG sialylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 2.0e-51
N 1,960
Large GWAS
European

IgG monosialylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 7.0e-42
N 1,960
Large GWAS
European

IgG disialylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 2.0e-13
N 1,960
Large GWAS
European

N-glycan measurement

Sharapov S et al. “A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.” Nature Communications 16(1):5525 (2025)
Allele A
OR 0.43
p 3.0e-127
N 7,540
Large GWAS
multi-ancestry

About ST6GAL1

This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

View all ST6GAL1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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