rs117238625

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

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Research that mentions this SNP (1)

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The dual and opposite role of the TM6SF2‐rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta‐analysis
AssociationN=13,577Carlos J. Pirola et al.(2015)· Hepatology

This doctoral thesis comprises three studies on metabolic syndrome-related traits. Study III is a GWAS identifying seven novel loci associating with circulating inflammatory markers (cytokines and adhesion molecules) in 5,284 Finnish individuals from NFBC1966, with meta-analysis including three additional Finnish populations totaling 13,577 participants. Studies I and II use Mendelian randomization and association analysis to examine metabolic effects of lipid-lowering therapies and NAFLD risk alleles (PNPLA3 rs738409-G, TM6SF2 rs58542926-T, GCKR rs780094-T/rs1260326-T, LYPLAL1 rs12137855-C, and NCAN rs2228603-T).

Traits studied:Cardiovascular diseaseCirculating inflammatory markersCytokines and cell adhesion moleculesIL1-betaIL1-receptor antagonistIL17IL4IL6IL8IP10Lipid metabolismMCP1Metabolic syndromeNon-alcoholic fatty liver disease (NAFLD)Soluble E-selectinSoluble ICAM-1Soluble VCAM-1TNF-alphaType 2 diabetes riskVEGF
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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