rs11725502

This is a upstream gene variant variant in the UGT2B10 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

plasma N-desmethylclozapine measurement

Pardiñas AF et al. “Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism.” The American Journal of Psychiatry 176(6):477-486 (2019)

Allele T

OR —

p 5.0e-15

N 2,989

Large GWAS

European

About UGT2B10

Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all UGT2B10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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