rs11736427

This is a 3 prime utr variant variant in the NIPAL1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of ceramide

Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)

Allele T

OR 0.21

p 3.0e-20

N 4,492

Large GWAS

European

glycosyl-N-stearoyl-sphingosine (d18:1/18:0) measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele T

OR 0.10

p 3.0e-11

N 8,233

Large GWAS

European

urate measurement

Cho C et al. “Large-scale cross-ancestry genome-wide meta-analysis of serum urate.” Nature Communications 15(1):3441 (2024)

Allele A

OR 0.01

p 3.0e-9

N 1,029,323

Meta-analysisLarge GWAS

multi-ancestry

About NIPAL1

Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]