rs11740768

This variant is located in the UIMC1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

uterine fibroid, age at menopause

Xiao C et al. “Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis.” American Journal of Obstetrics and Gynecology 230(4):438.e1-438.e15 (2024)

Allele A

OR —

p 2.0e-171

N 504,302

Large GWAS

European

About UIMC1

This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

View all UIMC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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