rs117565607
This is a intron variant variant in the TRIM26 gene.
▶Research that mentions this SNP (1)
▶A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune responseAssociationN=3,202Xiao‐Ming Lyu et al.(2018)· Cancer Medicine
A two-stage association study of 1,065 nasopharyngeal carcinoma (NPC) cases and 2,137 Southern Chinese controls identified rs117565607 in TRIM26 as significantly associated with NPC risk (OR=1.909, P=2.75×10⁻¹⁹). Functional studies demonstrated that the A allele reduces TRIM26 expression through impaired YY1 transcription factor binding, and TRIM26 downregulation is associated with suppressed immune response pathways in NPC tissues.
About TRIM26
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
View all TRIM26 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…