rs117618124

This is a intron variant variant in the GAREM1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

breast carcinoma

Michailidou K et al. “Association analysis identifies 65 new breast cancer risk loci.” Nature 551(7678):92-94 (2017)

Allele T

OR 1.12

p 6.0e-12

N 139,274

Large GWAS

multi-ancestry

Shu X et al. “Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.” Nature Communications 11(1):1217 (2020)

Allele T

OR 1.11

p 1.0e-11

N 277,932

Large GWAS

multi-ancestry

About GAREM1

This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

View all GAREM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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