rs11763750

This is a intron variant variant in the MAD1L1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

depressive disorder

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.04

p 1.0e-12

N 599,361

Major Consortium StudyLarge GWAS

multi-ancestry

sleep duration trait

Dashti HS et al. “Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.” Nature Communications 10(1):1100 (2019)

Allele G

OR 1.04

p 5.0e-9

N 411,934

Large GWAS

European

suicidal ideation, suicide behaviour

Kimbrel NA et al. “Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.” Jama Psychiatry 80(2):135-145 (2023)

Allele A

OR —

p 6.0e-9

N 452,767

Large GWAS

European

About MAD1L1

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]