rs1176746
This is a intron variant variant in the HTR3B gene.
▶Research that mentions this SNP (1)
▶Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependenceAssociationN=6,899Chamindi Seneviratne et al.(2013)· Human Genetics
This case-control association study examined 22 SNPs in HTR3A, HTR3B, and SLC6A4 genes in relation to alcohol dependence in 500 cases and 280 controls of European descent. Low-frequency variants rs33940208 (HTR3A) and rs2276305 (HTR3B) showed protective effects (OR=0.212, P=0.004 and OR=0.261, P=0.016 respectively). Gene-by-gene interaction analyses revealed significant interactive effects among SLC6A4, HTR3A, and HTR3B variants on alcohol dependence risk (OR=2.71-3.095, P<0.001-2×10⁻⁴). Findings were replicated in 6,699 samples from the OZ-ALC-GWAS study.
About HTR3B
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
View all HTR3B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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