rs11787664

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

tenascin measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele T
OR 0.23
p 7.0e-16
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
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Research that mentions this SNP (1)

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Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease
AssociationN=2,409Mollie A. Minear et al.(2011)· Human Genetics

This study identifies polymorphic variants in tenascin-C (TNC) associated with atherosclerosis and coronary artery disease across three independent datasets. Three SNPs (rs3789875, rs12347433, and rs4452883) in high linkage disequilibrium were significantly associated with disease risk, with the strongest evidence for rs3789875 (p=2×10⁻⁶, OR=3.4-4.5) and rs12347433 (p=5×10⁻⁶, OR=1.3-1.69), a synonymous coding variant in exon 22.

Traits studied:AtherosclerosisCoronary artery diseaseCoronary heart disease
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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