rs11788456
This is a intron variant variant in the GRIN3A gene.
▶Research that mentions this SNP (1)
▶Significant association of glutamate receptor, ionotropic N-methyl-d-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokersAssociationN=2,037Ma JZ et al.(2010)· Human Genetics
This family-based association study examined 25 SNPs in GRIN3A (glutamate receptor gene) in 2,037 individuals from 602 families (1,366 African-American, 671 European-American) for association with nicotine dependence measured by smoking quantity, heaviness of smoking index, and Fagerström test. SNPs rs17189632 and rs10121600 showed significant associations with all three nicotine dependence measures in the pooled sample (p=0.0002-0.0003), with rs17189632 remaining significant after correction for multiple testing. Haplotype-based analysis identified Block 1 (rs7030238-rs10512282) significantly associated with all measures across all populations.
About GRIN3A
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]
View all GRIN3A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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