rs117903946

This is a intron variant variant in the ZDHHC1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

comparative body size at age 10, self-reported

Richardson TG et al. “Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.” Bmj (clinical Research Ed.) 369:m1203 (2020)

Allele G

OR 0.03

p 3.0e-16

N 453,169

Large GWAS

European

body mass index

Hawkes G et al. “Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.” Diabetologia 66(8):1472-1480 (2023)

Allele G

OR 0.04

p 3.0e-11

N 441,761

Large GWAS

European

About ZDHHC1

Enables protein-cysteine S-palmitoyltransferase activity. Involved in antiviral innate immune response; protein palmitoylation; and regulation of defense response. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all ZDHHC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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