rs117972357

This is a regulatory region variant variant in the LINC02318 gene.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

plasma protein metabolism disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 1.68
p 1.0e-25
N 627,057
Major Consortium StudyLarge GWAS
multi-ancestry

Paraproteinemia

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 1.72
p 2.0e-22
N 631,415
Major Consortium StudyLarge GWAS
multi-ancestry

CD5 antigen-like measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.46
p 1.0e-19
N 47,745
Large GWAS
European

immunoglobulin J chain measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.45
p 5.0e-17
N 47,745
Large GWAS
European

amino acid metabolism disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 1.22
p 5.0e-15
N 620,597
Major Consortium StudyLarge GWAS
multi-ancestry

Fc receptor-like protein 2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.31
p 3.0e-13
N 47,745
Large GWAS
European

lymphoma

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 1.44
p 3.0e-8
N 668,480
Large GWAS
multi-ancestry

lymphocyte count

Orrù V et al. “Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.” Nature Genetics 52(10):1036-1045 (2020)
Allele A
OR 0.80
p 4.0e-8
N 3,656
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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