rs1181388

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

nephrotic syndrome

Barry A et al. “Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome.” Nature Communications 14(1):2481 (2023)

Allele A

OR 0.73

p 5.0e-11

N 9,091

Large GWAS

East Asian

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Research that mentions this SNP (1)

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Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?

AssociationN=1,497Marna G. Bouwhuis et al.(2010)· Cancer Immunology, Immunotherapy

This case-control study examined 28 SNPs across CD28, CTLA4, and ICOS genes in 763 German melanoma patients and 734 controls to assess association with melanoma susceptibility and prognosis. While two CD28 polymorphisms (rs3181098 and rs3181100) showed differential allele distribution (OR 1.18, P=0.05 and OR 0.83, P=0.02 respectively), after multiple testing correction no convincing associations with melanoma risk or disease prognosis were detected.

Traits studied:Melanoma prognosisMelanoma susceptibilityMetastasis-free survivalOverall survival

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs1181388

GWAS Catalog Trait Associations (1)

nephrotic syndrome

Research that mentions this SNP (1)

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