rs11838776

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

coronary artery disease

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele A
OR 0.02
p 1.0e-11
N 640,258
Large GWAS
European, East Asian
Nikpay M et al. “A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.” Nature Genetics 47(10):1121-1130 (2015)
Allele A
OR 1.07
p 1.0e-10
N 187,599
Meta-analysisLarge GWAS
multi-ancestry

white matter hyperintensity measurement

Persyn E et al. “Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.” Nature Communications 11(1):2175 (2020)
Allele A
OR 5.56
p 8.0e-11
N 45,204
Large GWAS
multi-ancestry
Armstrong NJ et al. “Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.” Stroke 51(7):2111-2121 (2020)
Allele A
OR 0.04
p 3.0e-8
N 18,226
Large GWAS
multi-ancestry

white matter integrity, age at assessment

Traylor M et al. “The BS variant of C4 protects against age-related loss of white matter microstructural integrity.” Brain : a Journal of Neurology 145(1):295-304 (2022)
Allele A
OR —
p 2.0e-10
N 31,128
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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