rs11841272

This is a regulatory region variant variant in the TNFRSF19 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

bone tissue density

Pei YF et al. “Joint Association Analysis Identified 18 New Loci for Bone Mineral Density.” Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 34(6):1086-1094 (2019)

Allele T

OR 0.04

p 2.0e-9

N 66,628

Large GWAS

About TNFRSF19

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

View all TNFRSF19 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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