rs11847263

This is a intron variant variant.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum IgG glycosylation measurement

Klarić L et al. “Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.” Science Advances 6(8):eaax0301 (2020)
Allele G
OR 0.28
p 1.0e-58
N 8,090
Large GWAS
European
Lauc G et al. “Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.” Plos Genetics 9(1):e1003225 (2013)
Allele G
OR 0.31
p 1.0e-22
N 2,247
Large GWAS
European
Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 3.0e-15
N 1,960
Large GWAS
European
Wahl A et al. “Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.” Frontiers in Immunology 9:277 (2018)
Allele G
OR 0.33
p 7.0e-17
N 1,823
Large GWAS
European

N-glycan measurement

Sharapov S et al. “A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.” Nature Communications 16(1):5525 (2025)
Allele G
OR 0.20
p 8.0e-33
N 10,172
Large GWAS
European

low affinity immunoglobulin gamma Fc region receptor III-B measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele T
OR 0.13
p 3.0e-20
N 10,708
Large GWAS
European

IgG monogalactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 1.0e-17
N 1,960
Large GWAS
European

IgG digalactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 3.0e-16
N 1,960
Large GWAS
European

IgG galactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 1.0e-15
N 1,960
Large GWAS
European

IgG sialylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 5.0e-15
N 1,960
Large GWAS
European

IgG monosialylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 6.0e-15
N 1,960
Large GWAS
European

IgG fucosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele G
OR —
p 6.0e-10
N 1,960
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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