rs11854957
This is a synonymous variant in the ISLR gene — it does not change the protein's amino acid sequence.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
blood protein amount
Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele T
OR 0.19
p 6.0e-17
N 5,366
Large GWAS
European
urate measurement
Gill D et al. “Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.” Hypertension (dallas, Tex. : 1979) 77(2):383-392 (2021)
Allele T
OR 0.01
p 1.0e-9
N 454,183
Meta-analysisLarge GWAS
European
About ISLR
Predicted to be involved in cell adhesion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
View all ISLR variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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