rs11866328

This is a intron variant variant in the GRIN2A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hepatitis B virus infection

Liu L et al. “A genome-wide association study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that affects disease progression of chronic HBV infection.” Viral Immunology 24(5):397-402 (2011)

Allele G

OR 1.68

p 2.0e-8

N 2,798

Large GWAS

East Asian

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ClinVar annotation

Benign★★★☆

2 submitters1 publication

View on ClinVar →

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Research that mentions this SNP (1)

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Association of GRIN1 and GRIN2A‐D With schizophrenia and genetic interaction with maternal herpes simplex virus‐2 infection affecting disease risk

AssociationN=2,484Ditte Demontis et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This Danish case-control association study examined SNP variations in GRIN1 and GRIN2A-D genes (encoding NMDA receptor subunits) in 984 schizophrenia cases and 1,500 controls. Nine SNPs in GRIN2B were significantly associated with schizophrenia, with rs1806194 remaining significant after Bonferroni correction (P=0.0008). Notably, strong gene-environment interactions were found between GRIN2B genetic variation and maternal HSV-2 infection in 365 cases and 365 controls, with rs1805539 (P=0.0001) and rs1806205 (P=0.0008) remaining significant after correction.

Traits studied:Schizophrenia

PubMed DOI Metascience Observatory

About GRIN2A

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]