rs1187280

This variant is located in the NTRK2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

anxiety disorder

Purves KL et al. “A major role for common genetic variation in anxiety disorders.” Molecular Psychiatry 25(12):3292-3303 (2020)

Allele G

OR 0.13

p 7.0e-9

N 83,566

Large GWAS

European

About NTRK2

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

View all NTRK2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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