rs11878583
This is a downstream gene variant variant in the ZNF577 gene.
▶Research that mentions this SNP (1)
▶Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibilityAssociationN=3,064Badan Sehrawat et al.(2011)· Human Genetics
A two-stage genome-wide association study (GWAS) identified six novel breast cancer susceptibility loci in a Canadian cohort (3,064 total participants). In Stage I, 348 cases and 348 controls were genotyped on Affymetrix SNP 6.0 arrays (906,600 SNPs), with 35 candidate variants selected for replication in Stage II (1,153 cases and 1,215 controls). Six SNPs showed significant association with breast cancer: rs1092913 in ROPN1L (OR 1.45, p=1.89×10⁻⁶), three ZNF577 SNPs (rs10411161, rs3848562, rs11878583; ORs 1.35-1.42), rs1429142 near EDNRA (OR 1.27), and rs1981867 near C16orf61 (OR 1.22). While not significant after genome-wide correction, these represent potential novel candidate loci warranting further validation.
About ZNF577
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNF577 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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